Aseptically administer 1 mL subcutaneously. Directions:įollowing the advice of the American Veterinary Medical Association on Vaccination Principles, an appropriate revaccination program for individual animals should be made based upon veterinarian-client-patient relationships.ġ. These factors should be considered by the user when evaluating product performance or freedom from reactions. This level of performance may be affected by conditions of use such as stress, weather, nutrition, disease, parasitism, other treatments, individual idiosyncrasies or impaired immunological competency. This product has been tested under laboratory conditions and shown to meet all Federal Standards for safety and ability to immunize normal healthy animals. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.ġ0. As with many vaccines, anaphylaxis may occur after use. Contains gentamicin and thimerosal as preservatives.ĩ. Do not vaccinate within 21 days before slaughter.Ĩ. Sterilized syringes and needles should be used to administer this vaccine.ħ. This product has not been tested in pregnant animals.Ħ. In case of human exposure, contact a physician.ĥ. Prolonged exposure to higher temperatures may adversely affect potency. Cattle and sheep were likewise protected one year after receiving a 2 mL dose of Nobivac 3-Rabies.ġ. Ferrets were protected against virulent challenge administered 1 year after vaccination. Department of Agriculture direction, demonstrated that a 1 mL dose met federal guidelines for protection of dogs and cats against virulent challenge administered 3 years after vaccination. Nobivac 3-Rabies has proven to be uniformly safe in experimental tests and no significant adverse reactions were reported in extensive clinical trials of the vaccine.ĭuration of immunity studies, conducted in accordance with federal regulation and under U.S.
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In addition, use of an established cell line yields a vaccine of consistent potency from serial to serial. The established cell line used in Nobivac 3-Rabies has been extensively tested for freedom from contaminating agents. Tissue-origin vaccines contain extraneous protein in addition to rabies antigen that can lead to autoimmune disease. Safety And Efficacyīecause Nobivac 3-Rabies vaccine is produced on an established cell line, it has safety advantages over inactivated brain-origin rabies vaccines. Respiratory failure is the immediate cause of death. “Furious rabies” is characterized by unusual aggression “dumb rabies” by lethargy and a desire to avoid contact.
Following infection, a paralytic syndrome ensues, emerging as either the “furious” or “dumb” form. The route of infection can be oral, respiratory, or parenteral. Rabies is not a treatable disease and suspect pets are usually quarantined until a clinical diagnosis is made, at which time they are destroyed. 2 Susceptibility to rabies varies according to pet species. In 1990, a total of 4,881 cases of animal rabies were reported to the Center for Disease Control by all 50 states, the District of Columbia and Puerto Rico. Since 1980, the most commonly reported rabid domestic animals have been cats, cattle and dogs. 1 Domestic animals are the major source of exposure for humans.
more than 30,000 people undergo treatment every year for possible exposure. Despite successful attempts over the years to reduce the incidence of rabies, recent published reports indicate that in the U.S. Wild animals are common vectors of the disease and the major source of transmission to humans and domestic animals. Rabies is a worldwide, high mortality disease affecting mammalian species. The inactivated virus is formulated with a highly purified adjuvant and is packaged in liquid form. The seed virus is a highly immunogenic, fixed strain of rabies virus which originated from Louis Pasteur’s original isolate in 1882. The vaccine is prepared from cell-culture-grown, chemically-inactivated rabies virus. Nobivac ® 3-Rabies vaccine is for vaccination of healthy dogs, cats, ferrets, cattle and sheep as an aid in preventing rabies. LICENSED FOR DOGS, CATS, FERRETS, CATTLE AND SHEEP Product Description IN THE ABSENCE OF A VETERINARIAN-CLIENT-PATIENT RELATIONSHIP, FEDERAL REGULATIONS PROHIBIT THE RELABELING, REPACKAGING, RESALE, OR REDISTRIBUTION OF THE INDIVIDUAL CONTENTS OF THIS PACKAGE.ĭIRECTIONS FOR USE - PLEASE READ CAREFULLY Annual Revaccination: Ferrets, Cattle & Sheep
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